FEATURES

FAMILY

DESCRIPTION

Also known as TM175_HUMAN, TMEM175. Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes (PubMed:26317472, PubMed:28723891, PubMed:32267231, PubMed:33505021, PubMed:32228865). Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion (PubMed:26317472, PubMed:28723891, PubMed:32267231, PubMed:33505021, PubMed:32228865). Constitutes the major lysosomal potassium channel (PubMed:26317472, PubMed:28723891). Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors (PubMed:33505021). The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation (PubMed:33505021). The lysoK(GF) complex is required to protect neurons against stress-induced damage (PubMed:33505021). Homodimer (Probable) (PubMed:32228865). Interacts with AKT (AKT1, AKT2 or AKT3); leading to formation of the lysoK(GF) complex, which activates the channel (PubMed:33505021).

EXTERNAL LINKS

TMEM175

Endosomal/lysosomal potassium channel TMEM175

TMEM175

Molecular Synopsis