FEATURES

DESCRIPTION

Also known as MTA3_HUMAN, MTA3, KIAA1266. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with BCL6. Interacts with NACC2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MTA3

Metastasis-associated protein MTA3

MTA3

Molecular Synopsis