FEATURES

DESCRIPTION

Also known as TPSNR_HUMAN, TAPBPL. Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Interacts with peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange onto higher affinity peptides.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TAPBPL

Tapasin-related protein

TAPBPL

Molecular Synopsis