FEATURES

DESCRIPTION

Also known as PLVAP_HUMAN, PLVAP, FELS, PV1. Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLVAP

Plasmalemma vesicle-associated protein

PLVAP

Molecular Synopsis