FEATURES

FAMILY

DESCRIPTION

Also known as CRNL1_HUMAN, CRNKL1, CRN. Involved in pre-mRNA splicing process. Identified in the spliceosome C complex (PubMed:11991638, PubMed:28502770, PubMed:28076346). Present in a spliceosome complex assembled in vitro containing CRNKL1, HPRP8BP and SNRPB2 (PubMed:12084575). Isoform 2 seems to be predominant in the spliceosome complex (PubMed:12084575). Interacts with PPIL2 (via the PPIase cyclophilin-type domain); they may form a trimeric complex with HSP90 (PubMed:15189447).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRNKL1

Mutations

Mutation(s) distribution

Mutations table