FEATURES

FAMILY

DESCRIPTION

Also known as SEM4C_HUMAN, SEMA4C, KIAA1739, SEMAI. Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SEMA4C

Semaphorin-4C

SEMA4C

Molecular Synopsis