FEATURES

DESCRIPTION

Also known as CTDS1_HUMAN, CTDSP1, NIF3, NLIIF, SCP1. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Monomer (By similarity). Interacts with GTF2F1. Interacts with REST.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CTDSP1

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

CTDSP1

Molecular Synopsis