FEATURES

FAMILY

DESCRIPTION

Also known as NDST4_HUMAN, NDST4, HSST4. Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NDST4

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

NDST4

Molecular Synopsis