FEATURES

FAMILY

DESCRIPTION

Also known as SG196_HUMAN, POMK, SGK196. Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1, 3-N-acetylglucosamine (GlcNAc)-beta-1, 4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1, 3-N-acetylglucosamine-beta-1, 4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

EXTERNAL LINKS

POMK

Protein O-mannose kinase

POMK

Molecular Synopsis