FEATURES

FAMILY

DESCRIPTION

Also known as ZCHC4_HUMAN, ZCCHC4. rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31799605, PubMed:31695039). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605). Interacts with components of the ASC-1 complex TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:31799605). Interact with AHCYL1 and AHCYL2 (PubMed:31799605). Interact with YTHDC2 (PubMed:31799605).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZCCHC4

rRNA N6-adenosine-methyltransferase ZCCHC4

Mutations

Mutation(s) distribution

Mutations table

Search Mutation