FEATURES

FAMILY

DESCRIPTION

Also known as CLK4_HUMAN, CLK4. Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Interacts with UBL5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CLK4

Dual specificity protein kinase CLK4

CLK4

Molecular Synopsis