FEATURES

DESCRIPTION

Also known as PNKP_MOUSE, Pnkp. Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. Monomer (PubMed:15749016). Interacts (via FHA domain) with XRCC4; mainly interacts with XRCC4 phosphorylated by CK2 but is also able to interact at much lower level with unphosphorylated PNKP (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Pnkp

Mutations

Mutation(s) distribution

Mutations table