FEATURES

FAMILY

DESCRIPTION

Also known as ATDA_VIBCH, speG. Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine. It can use polyamines such as spermine and N(1)-acetylspermine, but not putrescine or cadaverine. Homododecamer; dimer of hexamers (PubMed:25623305, PubMed:26410587). Exists in solution in a variety of protein homooligomeric states including dodecamers in an open state. The presence of the polyamines spermidine or spermine shifts the equilibrium to dodecamers and induces the formation of the closed, symmetric dodecamers (PubMed:26410587).

EXTERNAL LINKS

speG

Mutations

Mutation(s) distribution

Mutations table