FEATURES

DESCRIPTION

Also known as LIGO1_MACFA, LINGO1. Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). Homotetramer. Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity). Interacts with NGRF, RTN4R and MYT1L (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

LINGO1

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

LINGO1

Structural Ligandability

Domains Chains

Distribution