FEATURES

FAMILY

gamma type-C retroviral envelope protein family

DESCRIPTION

Also known as ENH1_HUMAN, ENH1. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties but has immunosuppressive properties in vivo., SU mediates receptor recognition., TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

EXTERNAL LINKS

ENH1

HERV-H_2q24.3 provirus ancestral Env polyprotein

ENH1

Molecular Synopsis