FEATURES

FAMILY

DESCRIPTION

Also known as RPR1B_HUMAN, RPRD1B, C20orf77, CREPT. Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Homodimer (PubMed:24997600). May form a heterodimer with RPRD1A (PubMed:24997600). Associates with RPAP2 (PubMed:24997600). Associates with the RNA polymerase II complex (PubMed:22231121, PubMed:24399136, PubMed:24997600).

EXTERNAL LINKS

RPRD1B

Regulation of nuclear pre-mRNA domain-containing protein 1B

RPRD1B

Molecular Synopsis