FEATURES

FAMILY

DESCRIPTION

Also known as SDHF2_HUMAN, SDHAF2, C11orf79, PGL2, SDH5. Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. Interacts with SDHA within the SDH catalytic dimer.

Also known as SDHF2_HUMAN, SDHAF2, C11orf79, PGL2, SDH5. Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) t ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SDHAF2

Succinate dehydrogenase assembly factor 2, mitochondrial

SDHAF2

Molecular Synopsis