FEATURES

FAMILY

DESCRIPTION

Also known as ELOV5_HUMAN, ELOVL5, ELOVL2. Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity).

EXTERNAL LINKS

ELOVL5

Elongation of very long chain fatty acids protein 5

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

ELOVL5

Structural Ligandability

Domains Chains

Distribution