FEATURES

FAMILY

DESCRIPTION

Also known as ERAP1_HUMAN, ERAP1, APPILS, ARTS1, KIAA0525. Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.

Also known as ERAP1_HUMAN, ERAP1, APPILS, ARTS1, KIAA0525. Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. P ...

EXTERNAL LINKS

ERAP1

Endoplasmic reticulum aminopeptidase 1

ERAP1

Molecular Synopsis