FEATURES

DESCRIPTION

Also known as ARHGC_HUMAN, ARHGEF12, KIAA0382, LARG. May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Interacts with GNA12 and GNA13, probably through the RGS-like domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts through its PDZ domain with IGF1R beta subunit. Interacts with GCSAM.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ARHGEF12

Rho guanine nucleotide exchange factor 12

ARHGEF12

Molecular Synopsis