FEATURES

FAMILY

DESCRIPTION

Also known as SST2_SCHPO, sst2. Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.

EXTERNAL LINKS

uniprot
enzyme classification

sst2

Mutations

Mutation(s) distribution

Mutations table