FEATURES

FAMILY

DESCRIPTION

Also known as TRPC4_MOUSE, Trpc4, Trrp4. Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells. Homotetramer (PubMed:19070363). Heterotetramer with TRPC1 and/or TRPC5 (By similarity). Isoform alpha but not isoform beta interacts with ITPR1, ITPR2 and ITPR3 (By similarity). Interacts with SLC9A3R1/NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts (via CIRB domain) with SESTD1 (via the spectrin 1 repeat) and SPTBN5 (via C-terminus) (By similarity). Interacts with CDH5 and CTNNB1 (By similarity). Interacts (via protein 4.1-binding domain) with EPB41L2 (By similarity). Interacts with TRPC4AP (PubMed:20458742). Interacts with PLSCR1 (PubMed:32110987).

EXTERNAL LINKS

Trpc4

Mutations

Mutation(s) distribution

Mutations table