FEATURES

FAMILY

DESCRIPTION

Also known as IIGP1_MOUSE, Iigp1, Irga6. GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. Monomer, as apoenzyme and in the GDP-bound form. Homooligomer, upon GTP binding. Interacts with HOOK3.

EXTERNAL LINKS

uniprot
enzyme classification

Iigp1

Mutations

Mutation(s) distribution

Mutations table