FEATURES

FAMILY

DESCRIPTION

Also known as SCAS_MESMA, SCAS. Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. It binds to distinct receptor sites of mammal and insect voltage-gated sodium channels. It displays antinociceptive effect in rat models, which is due to its specific modulation of sodium channels of sensory neurons. It also significantly stimulates the binding of [3H]-ryanodine to ryanodine receptors on the sarcoplasmic reticulum of the skeletal muscle through an indirect mechanism. And it promotes noradrenaline release from the rat hippocampus slice.

EXTERNAL LINKS

SCAS

Beta-toxin BmKAS

SCAS

Molecular Synopsis