FEATURES

FAMILY

DESCRIPTION

Also known as MGT4C_HUMAN, MGAT4C. Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MGAT4C

Alpha-1, 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

MGAT4C

Molecular Synopsis