FEATURES

FAMILY

DESCRIPTION

Also known as TRPC4_HUMAN, TRPC4. Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC5 (PubMed:12032305). Isoform alpha but not isoform beta interacts with ITPR1, ITPR2 and ITPR3 (PubMed:11163362). Interacts with (via PDZ-binding domain) with SLC9A3R1/NHERF (PubMed:12154080). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865). Interacts (via CIRB domain) with SESTD1 (via spectrin 1 repeat) (PubMed:20164195). Interacts with CDH5 and CTNNB1 (PubMed:19996314). Interacts with SPTAN1 (via C-terminal spectrin repeats) and SPTBN5 (via C-terminus) (PubMed:18048348). Interacts (via protein 4.1-binding domain) with EPB41L2 (PubMed:16254212). Interacts with PLSCR1 (By similarity).

EXTERNAL LINKS

TRPC4

Short transient receptor potential channel 4

TRPC4

Molecular Synopsis