FEATURES

FAMILY

DESCRIPTION

Also known as SCNBA_HUMAN, SCN11A, SCN12A, SNS2. This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.

EXTERNAL LINKS

SCN11A

Sodium channel protein type 11 subunit alpha

SCN11A

Molecular Synopsis