FEATURES

FAMILY

DESCRIPTION

Also known as TRM6_HUMAN, TRMT6, KIAA1153, TRM6. Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A.

Also known as TRM6_HUMAN, TRMT6, KIAA1153, TRM6. Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRMT6

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

TRMT6

Molecular Synopsis