FEATURES

DESCRIPTION

Also known as KLH21_HUMAN, KLHL21, KIAA0469. Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KLHL21

Kelch-like protein 21

KLHL21

Molecular Synopsis