FEATURES

FAMILY

DESCRIPTION

Also known as MA1B1_HUMAN, MAN1B1. Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1, 2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAN1B1

Endoplasmic reticulum mannosyl-oligosaccharide 1, 2-alpha-mannosidase

MAN1B1

Molecular Synopsis