FEATURES

FAMILY

DESCRIPTION

Also known as PLXB3_HUMAN, PLXNB3, KIAA1206, PLXN6. Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLXNB3

Plexin-B3

PLXNB3

Molecular Synopsis