FEATURES

FAMILY

DESCRIPTION

Also known as LORF1_HUMAN, L1RE1, LRE1. Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. Homotrimer (via coiled coil domain). May also form larger homooligomers. May interact with DDX39A, HNRNPA1, SERBP1 and YBX1. Interacts with TEX19 and UBR2 (PubMed:28806172). Interacts with MOV10 (PubMed:23093941).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

L1RE1

LINE-1 retrotransposable element ORF1 protein

L1RE1

Molecular Synopsis