FEATURES

FAMILY

DESCRIPTION

Also known as TNF18_HUMAN, TNFSF18, AITRL, GITRL, TL6. Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). Homodimer (By similarity). Homotrimer.

EXTERNAL LINKS

TNFSF18

Mutations

Mutation(s) distribution

Mutations table