FEATURES

FAMILY

DESCRIPTION

Also known as CP8B1_HUMAN, CYP8B1, CYP12. A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis (PubMed:10051404). Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (By similarity).

EXTERNAL LINKS

CYP8B1

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

CYP8B1

Molecular Synopsis