FEATURES

FAMILY

DESCRIPTION

Also known as LAMP3_HUMAN, LAMP3, DCLAMP, TSC403. Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752)., (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection., (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F., (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. Monomer (PubMed:22809326). Interacts with FURIN (PubMed:32295904).

EXTERNAL LINKS

LAMP3

Mutations

Mutation(s) distribution

Mutations table