FEATURES

FAMILY

eukaryotic-type primase large subunit family

DESCRIPTION

Also known as PRIL_SACS2, priL, priB. Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template-independent 3'-terminal nucleotidyl transferase activity. Heterodimer of a small subunit (PriS) and a large subunit (PriL).

EXTERNAL LINKS

priL

Mutations

Mutation(s) distribution

Mutations table