FEATURES

DESCRIPTION

Also known as SPART_DROME, spartin. During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival. Interacts with Eps-15 (via C-terminal region); the interaction is required for spartin localization to the NMJ presynaptic membrane.

spartin

Structural Ligandability

Domains Chains

Distribution