FEATURES

FAMILY

DESCRIPTION

Also known as RAD50_THEMA, rad50. Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity). Homodimer. Forms a complex with Mre11 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

rad50

Probable DNA double-strand break repair Rad50 ATPase

Mutations

Mutation(s) distribution

Mutations table

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