FEATURES

FAMILY

DESCRIPTION

Also known as TRPV5_RABIT, Trpv5, Ecac1. Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:10085067, PubMed:11035011, PubMed:12574114, PubMed:29323279). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:29323279). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (PubMed:11035011). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114). Homotetramer (PubMed:29323279). Probably forms heterotetramers with TRPV6 (PubMed:12574114). Interacts with TRPV6 (PubMed:12574114). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation.

EXTERNAL LINKS

Trpv5

Mutations

Mutation(s) distribution

Mutations table