FEATURES

DESCRIPTION

Also known as GLCNE_HUMAN, GNE, GLCNE. Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Homodimer and homohexamer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GNE

Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Mutations

Mutation(s) distribution

Mutations table

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