FEATURES

FAMILY

DESCRIPTION

Also known as KDM2A_HUMAN, KDM2A, CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004. Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CBX5/HP1A; the interaction promotes CBX5 localization to chromatin. The SKP1-KDM2A complex interacts with UBB (PubMed:30033217).

Also known as KDM2A_HUMAN, KDM2A, CXXC8, FBL11, FBL7, FBXL11, JHDM1A, KIAA1004. Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in his ...

EXTERNAL LINKS

KDM2A

Lysine-specific demethylase 2A

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

KDM2A

Structural Ligandability

Domains Chains

Distribution