FEATURES

FAMILY

DESCRIPTION

Also known as MEMO1_HUMAN, MEMO1, C2orf4, MEMO, NS5ATP7. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. Interacts with ERBB2 phosphorylated on 'Tyr-1248'.

Also known as MEMO1_HUMAN, MEMO1, C2orf4, MEMO, NS5ATP7. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MEMO1

Protein MEMO1

MEMO1

Molecular Synopsis