FEATURES

FAMILY

DESCRIPTION

Also known as HCN4_HUMAN, HCN4. Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HCN4

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Mutations

Mutation(s) distribution

Mutations table

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