FEATURES

FAMILY

Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family

DESCRIPTION

Also known as FLVC1_HUMAN, FLVCR1, FLVCR. Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro., Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. Interacts with HPX.

EXTERNAL LINKS

FLVCR1

Feline leukemia virus subgroup C receptor-related protein 1

FLVCR1

Molecular Synopsis