FEATURES

FAMILY

DESCRIPTION

Also known as ST14_HUMAN, ST14, PRSS14, SNC19, TADG15. Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Interacts with CDCP1. May interact with TMEFF1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ST14

Suppressor of tumorigenicity 14 protein

Mutations

Mutation(s) distribution

Mutations table

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