FEATURES

FAMILY

DESCRIPTION

Also known as PARD3_RAT, Pard3, Par3. Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:18550519). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390). Targets the phosphatase PTEN to cell junctions (PubMed:18082612). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts (via PDZ 1 domain) with PARD6A, PARD6B and F11R/JAM1. Interacts with AURKA, AURKB and SIRT2 (By similarity). Interacts with PRKCI. Interacts with PRKCZ (Probable). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Interacts with LIMK2 and CDH5. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2. Interacts with ECT2 and FBF1 (By similarity). Interacts (via PDZ 3 domain) with PTEN (via C-terminus). Interacts (via coiled-coil domain) with FRMD4A (By similarity). Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity). Interacts with SAPCD2 (By similarity). Interacts with PRKCA (By similarity).

EXTERNAL LINKS

Pard3

Partitioning defective 3 homolog

Pard3

Molecular Synopsis