FEATURES

FAMILY

DESCRIPTION

Also known as DESVI_STRVZ, desVI. S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of desosamine, found in certain macrolide antibiotics such as erthyromycin, azithromycin, clarithromycin, and methymycin. Catalyzes the last step in the biosynthesis of dTDP-desosamine, i.e. the N, N-dimethylation of the 3-amino group of dTDP-3-amino-3, 4, 6-trideoxy-alpha-D-glucose. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

desVI

dTDP-3-amino-3, 4, 6-trideoxy-alpha-D-glucopyranose N, N-dimethyltransferase

Structural Ligandability

Domains Chains

0 chains assessed

desVI

Structural Ligandability

Domains Chains

Distribution