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GENERAL
TITLE
CRYSTAL STRUCTURE OF DOT1L IN COMPLEX WITH INHIBITOR CPD1 [N6-(2,6- DICHLOROPHENYL)-N6-(PENT-2-YN-1-YL)QUINOLINE-4,6-DIAMINE] AND INHIBITOR CPD2 [(R)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-3- AMINE]
DATE LAST MODIFIED
5 Apr 2017
RELEASE
22 Mar 2017
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 63
RESOLUTION RANGE HIGH
2.09
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACSMEDCHEMLETT.6B00519

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q8TEK3 DOT1L, KIAA1814, KMT4 ESCHERICHIA COLI HUMAN
DOT1-LIKE PROTEIN,HISTONE H3-K79 METHYLTRANSFERASE ...
Mutations
Q8TEK3 DOT1L, KIAA1814, KMT4 ESCHERICHIA COLI HUMAN
DOT1-LIKE PROTEIN,HISTONE H3-K79 METHYLTRANSFERASE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402