5MW3

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CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 5MW3_A

Chain 5MW3_B

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GENERAL

TITLE

CRYSTAL STRUCTURE OF DOT1L IN COMPLEX WITH INHIBITOR CPD1 [N6-(2,6- DICHLOROPHENYL)-N6-(PENT-2-YN-1-YL)QUINOLINE-4,6-DIAMINE] AND INHIBITOR CPD2 [(R)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-3- AMINE]

DATE LAST MODIFIED

5 Apr 2017

RELEASE

22 Mar 2017

OBSOLETE

CLASSIFICATION

TRANSFERASE

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 63

RESOLUTION RANGE HIGH

2.09

RESOLUTION RANGE LOW

PUBMED ID

28337327

DOI

10.1021/ACSMEDCHEMLETT.6B00519

PDBe

5MW3

LIGANDS

2976806 , 93764 , 67113

Chains

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q8TEK3	DOT1L, KIAA1814, KMT4	ESCHERICHIA COLI	HUMAN	DOT1-LIKE PROTEIN,HISTONE H3-K79 METHYLTRANSFERASE ...	Mutations
	P81947	DOT1L, KIAA1814, KMT4	ESCHERICHIA COLI	HUMAN	DOT1-LIKE PROTEIN,HISTONE H3-K79 METHYLTRANSFERASE ...

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402