FEATURES

FAMILY

DESCRIPTION

Also known as PHKG1_RABIT, PHKG1, PHKG. Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3. Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

EXTERNAL LINKS

uniprot
enzyme classification

PHKG1

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

Mutations

Mutation(s) distribution

Mutations table

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