FEATURES

FAMILY

DESCRIPTION

Also known as RHO1_YEAST, RHO1. Acts as a central regulator in the cell wall integrity signaling pathway, which is regulated by the cell cycle and in response to various types of cell wall stress. Integrates signals from different cell surface sensors, and activates a set of effectors, regulating processes including beta-glucan synthesis at the site of wall remodeling, gene expression related to cell wall biogenesis, organization of the actin cytoskeleton, and protein- and secretory vesicle-targeting to the growth site. Activates the protein kinase C (PKC1) MAP kinase cascade, the beta-1, 3-glucan synthase (FKS1), the formin BNI1, the exocyst component SEC3 and the transcription factor SKN7. Interacts with the GAPs BAG7, LRG1, SAC7, and with RDI1. Interacts with the 1, 3-beta-glucan synthase component FKS1, with protein kinase PKC1, with the G protein beta subunit STE4 and with SKN7.

EXTERNAL LINKS

RHO1

Mutations

Mutation(s) distribution

Mutations table